ELK Biotechnology Ezrin (phospho Tyr353) rabbit pAb
Ezrin 단백질의 Tyr353 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 세포막-세포골격 연결 연구에 활용되며, 인간, 마우스, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Ezrin (phospho Tyr353) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Ezrin around the phosphorylation site of Tyr353. AA range: 321–370 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 69 kD |
| Gene ID (Human) | 7430 |
| Human Swiss-Prot No. | P15311 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Apical cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection; Microvillus membrane; Ruffle membrane; Cytoplasm, cell cortex; Cytoskeleton; Microvillus. Localization to the apical membrane of parietal cells depends on interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
배경 (Background)
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization, and has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described (RefSeq, Jul 2008).
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