ELK Biotechnology p53 (phospho Ser378) rabbit pAb

제품명

p53 (phospho Ser378) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 p53 단백질의 Ser378 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody입니다. 세포 내 p53의 발현 및 인산화 상태를 검출하는 데 유용하며, Western blot 및 ELISA 실험에 적합합니다.

제품 정보

세포 내 위치

Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and mitomycin C treatment (PubMed:27323408).

Isoform-specific localization:

• Isoform 1: Nucleus, Cytoplasm (predominantly nuclear)
• Isoform 2: Nucleus, minor cytoplasmic staining
• Isoform 3: Nucleus, occasionally cytoplasmic
• Isoform 4: Nucleus, translocates to cytoplasm when co-expressed

Background

Tumor protein p53 (TP53) is a tumor suppressor protein containing transcriptional activation, DNA-binding, and oligomerization domains. It responds to cellular stress by regulating target gene expression, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in TP53 are associated with various human cancers, including hereditary Li-Fraumeni syndrome. Alternative splicing and promoter usage generate multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]