ELK Biotechnology p53 (Acetyl K319) rabbit pAb
인간 p53 단백질의 Lys319 아세틸화 부위를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 고순도 IgG 형태로 제공되며, 인간·마우스·랫트 시료에 반응. 세포 내 p53 발현 및 위치 연구에 적합.
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ELK Biotechnology p53 (Acetyl K319) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | p53 (Acetyl K319) rabbit pAb |
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p53 around the acetylated site of Lys317 (AA range: 283–332) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kDa |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Translocates to mitochondria upon oxidative stress or mitomycin C treatment.
Isoform-specific localization:
- Isoform 1: Predominantly nuclear, cytoplasmic when co-expressed with isoform 4
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) in Homo sapiens encodes a tumor suppressor protein with transcriptional activation, DNA binding, and oligomerization domains. It responds to various cellular stresses to regulate target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in this gene are linked to numerous human cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms, with additional isoforms arising from alternative translation initiation codons (RefSeq, Feb 2013; PMIDs: 12032546, 20937277).
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