ELK Biotechnology Topo IIα (phospho Ser1525) rabbit pAb
Topo IIα (phospho Ser1525) rabbit polyclonal antibody for detection of phosphorylated TOP2A in human, mouse, and rat samples. Suitable for WB, IHC, IF, and ELISA. High specificity and sensitivity with 1 mg/ml concentration. Long-term storage at -20°C.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Topo IIα (phospho Ser1525) rabbit pAb
Topo IIα (phospho Ser1525) Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Topo IIα (phospho Ser1525) rabbit pAb |
| Alternative Names | TOP2A; TOP2; DNA topoisomerase 2-alpha; DNA topoisomerase II; alpha isozyme |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human TOP2A around the phosphorylation site of Ser1525 (AA range: 1482–1531) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 190 kD |
| Gene ID (Human) | 7153 |
| Human Swiss-Prot No. | P11388 |
| Cellular Localization | Cytoplasm; Nucleus; Nucleoplasm; Nucleolus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA, allowing the strands to pass through one another and altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The alpha gene is localized to chromosome 17, and the beta gene to chromosome 3. This enzyme functions as the target for several anticancer agents, and mutations in this gene have been associated with drug resistance. Reduced activity of this enzyme may also play a role in disease development.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.