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ELK Biotechnology Synuclein-α (phospho Ser129) rabbit pAb
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인산화된 Ser129 부위를 인식하는 Synuclein-α 폴리클로날 토끼 항체. WB, IHC, IF, ELISA에 사용 가능. 파킨슨병 및 알츠하이머병 연구에 적합. 사람, 생쥐, 랫트 반응성. -20°C에서 1년 보관.
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ELK Biotechnology · ELK Biotechnology Synuclein-α (phospho Ser129) rabbit pAb
Synuclein-α (phospho Ser129) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Synuclein-α (phospho Ser129) rabbit pAb |
| Alternative Names | SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129 (AA range: 91–140) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15 kD |
| Gene ID (Human) | 6622 |
| Human Swiss-Prot No. | P37840 |
| Cellular Localization | Cytoplasm, Membrane, Nucleus, Cell junction (synapse), Secreted, Cell projection (axon). Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at varicosities (By similarity). |
| Species Reactivity | Human; Mouse; Rat |
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain, and alpha- and beta-synuclein selectively inhibit phospholipase D2. SNCA may integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in Parkinson’s disease pathogenesis. SNCA peptides are a major component of amyloid plaques in Alzheimer’s disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. (RefSeq, Feb 2016)
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