
ELK Biotechnology BLM rabbit pAb
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Product name: | BLM rabbit pAb |
Alternative Names: | BLM; RECQ2; RECQL3; Bloom syndrome protein; DNA helicase; RecQ-like type 2; RecQ2; RecQ protein-like 3 |
Applications: | IHC;IF;ELISA |
Recommended Dilutions: | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
Immunogen: | The antiserum was produced against synthesized peptide derived from human Bloom Syndrome. AA range:65-114 |
Storage: | Rabbit |
Storage: | -20°C/1 year |
Clonality: | Polyclonal |
Isotype: | IgG |
Concentration: | 1 mg/ml |
GeneID(Human): | 641 |
Human Swiss-Prot No: | P54132 |
Cellular localization: | Nucleus . Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner. |
Background: | The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008], |
Species Reactivity: | Human;Rat;Mouse; |
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