Thermo Fisher Scientific p53 Polyclonal Antibody
Thermo Fisher Scientific의 p53 Polyclonal Antibody는 인간 p53 단백질을 인식하는 토끼 유래 다클론 항체로, WB, IHC, Flow, IP, ChIP-Seq 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 안정적 액상 형태로 제공됩니다.
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Thermo Fisher Scientific p53 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1.5 µg/1×10⁶ cells in 150 µL |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
| ChIP-sequencing (ChIP-Seq) | 4 µg/30 µg chromatin |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 50 and 100 of human tumor protein p53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation leads to transcription of genes such as p21waf1, regulating G1 or G2/M arrest.
Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is important for activation and stabilization. Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and functions as an anticancer agent. It is also linked to aging, oxidative stress, and learning/memory processes.
Mutations in the TP53 gene can lead to loss of tumor suppressor activity, contributing to malignancy. Germline mutations are found in cancer-prone families such as Li-Fraumeni syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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