Thermo Fisher Scientific CIITA Polyclonal Antibody
CIITA 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS 기반 완충액에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CIITA (Accession P33076), corresponding to amino acid residues L720–L770 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850549 |
Product Specific Information
This antibody detects endogenous levels of total CIITA.
Target Information
CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats), and a GTP binding domain. It is located in the nucleus and functions as a positive regulator of class II MHC gene transcription, often referred to as the “master control factor” for the expression of these genes. CIITA binds GTP, which facilitates its nuclear transport. Inside the nucleus, it acts as a coactivator via intrinsic acetyltransferase (AT) activity rather than direct DNA binding.
Mutations in CIITA are associated with bare lymphocyte syndrome type II (hereditary MHC class II deficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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