Thermo Fisher Scientific CD163 Monoclonal Antibody (TNKUPJ), eBioscience
마우스 CD163 단백질을 인식하는 TNKUPJ 클론 단일클론 항체로, 면역조직화학(IHC) 및 유세포분석(Flow Cytometry)에 적합합니다. 비결합형 액상 포맷이며, PBS(pH 7.2) 내 0.09% sodium azide를 포함합니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL | - |
| Flow Cytometry (Flow) | - | View 14 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TNKUPJ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865001 |
Available Conjugated Formats
- Alexa Fluor 532
- APC
- Brilliant UV 615, 661, 737, 805
- Brilliant Violet 421
- eFluor 450
- FITC
- PE, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 702
- Request custom conjugation
Product Specific Information
This TNKUPJ monoclonal antibody recognizes mouse CD163, a 130 kDa surface receptor expressed by specific subsets of tissue macrophages such as splenic red pulp macrophages, Kupffer cells, and intestinal lamina propria macrophages. Mouse monocytes do not express CD163, and unlike human CD163, it is not strongly induced by M2 polarizing cytokines.
This antibody detects CD163 on fixed and permeabilized cells, suitable for intracellular staining. Although CD163 is stable to collagenase digestion, harsh tissue dissociation may reduce surface expression; intracellular detection is recommended in such cases.
Applications Reported:
- Immunohistochemical staining of frozen tissue sections
- Flow cytometry (fluorochrome-conjugated TNKUPJ recommended)
Applications Tested:
- IHC (Frozen): ≤ 5 µg/mL (optimal dilution should be determined experimentally)
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein and a receptor for the hemoglobin-haptoglobin complex. It protects tissues from oxidative damage by mediating endocytosis of hemoglobin/haptoglobin complexes and contributes to iron recycling.
CD163 is expressed on monocytes and macrophages, particularly during the late phase of inflammation. Expression is upregulated by IL-10, IL-6, and dexamethasone, while LPS and PMA induce shedding of CD163 into plasma. Binding of CD163 to hemoglobin/haptoglobin complexes is calcium- and pH-dependent and triggers intracellular signaling cascades involving tyrosine kinase, calcium mobilization, and IL-6/CSF1 secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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