Thermo Fisher Scientific JARID1C Polyclonal Antibody
Thermo Fisher Scientific의 JARID1C Polyclonal Antibody는 인간 유래 단백질을 인식하는 토끼 IgG 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, TBS 버퍼에 0.1% BSA와 0.09% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1510 and the C-terminus (residue 1560) of human Jumonji, AT rich interactive domain 1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Dog, and Pig
Target Information
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking.
Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons.
Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway.
Phosphorylates: TANC1 upon stimulation by RAP2A, MBP, and SMAD1.
Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Isoform 4 can activate the JNK pathway.
Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion, and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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