Thermo Fisher Scientific RhoV Polyclonal Antibody
Rabbit polyclonal antibody against human RhoV protein. Suitable for IHC (Paraffin) applications with 1:50–1:200 dilution. Unconjugated, purified by antigen affinity chromatography. Stored in PBS with 40% glycerol and sodium azide. For research use only.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RhoV. Recombinant protein control fragment (Product #RP-104211). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646544 |
Product Specific Information
- Immunogen sequence: KEVFDSAILS AIEHKARLEK KLNAKGVRTL SRCRWKKFFC FV
- Highest antigen sequence identity to orthologs: Mouse - 100%, Rat - 100%.
Target Information
The Rho subfamily of Ras-related GTPases regulates various cellular functions such as cytoskeletal rearrangement, nuclear signaling, and cell growth.
RhoV (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP, or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway.
RhoV functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas, and fetal brain. It is implicated in cell transformation and encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
Diseases such as Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome are associated with defects in chromosome 15-localized genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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