Thermo Fisher Scientific WDR48 Polyclonal Antibody
Thermo Fisher Scientific의 WDR48 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 항체로, Western blot, IHC, ELISA에 적합합니다. WDR48 단백질의 WD-repeat 구조 연구에 활용되며, 높은 특이성과 안정성을 제공합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 450–677 of human WDR48 (NP_0658901) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901703 |
Product Specific Information
Positive Samples:
U-251MG, A-431, SGC-7901, LO2, A-549, HT-1080, Mouse brain, Rat testis
Immunogen Sequence:
FSSPDGSDPK LNLGGLLLQA LLEYWPRTHV NPMDEEENEV NHVNGEQENR VQKGNGYFQV PPHTPVIFGE AGGRTLFRLL CRDSGGETES MLLNETVPQW VIDITVDKNM PKFNKIPFYL QPHASSGAKT LKKDRLSASD MLQVRKVMEH VYEKIINLDN ESQTTSSSNN EKPGEQEKEE DIAVLAEEKI ELLCQDQVLD PNMDLRTVKH FIWKSGGDLT LHYRQKST
Target Information
WD-repeats are motifs found in various proteins characterized by a conserved core of 40–60 amino acids forming a propeller structure. Proteins containing WD-repeats are involved in signal transduction, apoptosis, transcriptional regulation, and cell cycle control.
WDR48 (WD repeat-containing protein 48), also known as USP1-associated factor 1 and p80, is a 677 amino acid protein that regulates deubiquitinating complexes via activation of USP1, USP12, and USP46. It enhances catalytic turnover without increasing substrate affinity. WDR48 is ubiquitously expressed and mainly localized in the cytoplasm, with five isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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