Thermo Fisher Scientific IRAK1 Recombinant Rabbit Monoclonal Antibody (JE60-03)
IRAK1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. HEK293 세포에서 발현되었으며 Protein A로 정제되었습니다. 인간 및 생쥐 시료에 반응하며 비결합형 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE60-03 |
| Immunogen | Recombinant protein within human IRAK-1 aa 201–500/712 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931297 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP to promote its ubiquitination and degradation, and phosphorylates IRF7 to induce its activation and nuclear translocation, resulting in transcriptional activation of type I IFN genes that drive antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-44841_IRAK1_P51617-1_Rabbit.svg, MA5-44841_IRAK1_P51617-1_Rabbit_PDP.jpeg)
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