Thermo Fisher Scientific GATA3 Polyclonal Antibody

Thermo Fisher Scientific GATA3 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:1,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human GATA3.

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 is an enhancer-binding protein containing a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage, participating in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene comprising six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.