Thermo Fisher Scientific Claudin 18 Polyclonal Antibody
Claudin-18 단백질을 인식하는 Rabbit Polyclonal 항체로, Human과 Mouse 시료에 반응합니다. Western blot, IHC(P), IHC(F) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunohistochemistry (IHC) | - | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the human Claudin-18 protein, which differs from mouse by 4 conservative amino acid replacements and one non-conservative amino acid replacement |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533382 |
Target Information
Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms generated by alternative splicing of the claudin-18 gene. The lung-specific form is regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain exists in mouse but not confirmed in human. Human claudin-18 shares 88% amino acid sequence identity with the mouse protein.
Immunohistochemical studies show complete membrane localization of Claudin-18 in lung and stomach epithelial cells, with concentration at cell-cell borders observed under electron microscopy. These findings suggest an important role in the structure and function of tight junctions in lung and stomach tissues. Claudin-18 expression has also been reported in the inner ear.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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