Thermo Fisher Scientific Claudin 18 Polyclonal Antibody
Claudin-18 단백질을 인식하는 Rabbit Polyclonal 항체로, Human과 Mouse 시료에 반응합니다. Western blot, IHC(P), IHC(F) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 388000
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Claudin 18 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunohistochemistry (IHC) | - | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the human Claudin-18 protein, which differs from mouse by 4 conservative amino acid replacements and one non-conservative amino acid replacement |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533382 |
Target Information
Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms generated by alternative splicing of the claudin-18 gene. The lung-specific form is regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain exists in mouse but not confirmed in human. Human claudin-18 shares 88% amino acid sequence identity with the mouse protein.
Immunohistochemical studies show complete membrane localization of Claudin-18 in lung and stomach epithelial cells, with concentration at cell-cell borders observed under electron microscopy. These findings suggest an important role in the structure and function of tight junctions in lung and stomach tissues. Claudin-18 expression has also been reported in the inner ear.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.