Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI1G7)
COMMD1 단백질을 표적하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone OTI1G7). Western Blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, 인체 반응성. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G7 |
| Immunogen | Full length human recombinant protein of COMMD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723003 |
Target Information
Proposed scaffold protein implicated in diverse physiological processes, partly linked to regulation of ubiquitination of specific cellular proteins. Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination and proteasomal degradation of NF-kappa-B subunit RELA, down-regulating NF-kappa-B activity. Regulates membrane expression and ubiquitination of SLC12A2, modulating Na(+) transport in epithelial cells. Promotes localization of SCNN1D to recycling endosomes and CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with homodimerization. Plays a role in copper ion homeostasis and ATP7A trafficking between trans-Golgi network and peripheral vesicles, dependent on CCC and WASH complex cooperation. Binds one copper ion per monomer and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in HIF1A-mediated transcription regulation by competing with ARNT/Hif-1-beta for HIF1A binding, reducing DNA binding and transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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