Thermo Fisher Scientific alpha-2b Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha-2B adrenergic receptor. Validated for WB, IHC, ICC, and Flow Cytometry. Provides high specificity and sensitivity. Suitable for neuroscience and receptor signaling research. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 343–369 of the central region of human ADRA2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2635064 |
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily and include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors play a key role in regulating neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
The alpha2B adrenergic receptor subtype associates with eIF-2B, a guanine nucleotide exchange protein involved in translation regulation. A polymorphic variant lacking three glutamic acids from a repeat element shows decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This variant is associated with reduced basal metabolic rate in obese individuals and may contribute to obesity pathogenesis.
The alpha2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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