Thermo Fisher Scientific PLA1A Polyclonal Antibody
Rabbit polyclonal antibody against human PLA1A for ICC/IF applications. Recognizes recombinant PLA1A protein with high specificity. Supplied as liquid, unconjugated form, purified by antigen affinity chromatography. Suitable for research use only.
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- PA566277
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- pk
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PLA1A. Recombinant protein control fragment (Product #RP-106963). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663481 |
Product Specific Information
Immunogen sequence:
QCQINQVKFKF QSSNRVWKKD RTTIIGKFCT ALLPVNDREK MVCLPEPVNL QASVTVSCDL KIAC
Highest antigen sequence identity to the following orthologs:
- Mouse: 71%
- Rat: 68%
Target Information
PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and apoptotic cells, and activates platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells.
A major function of PLA1A may be the production of lysophospholipid mediators.
PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft, and expressed in human THP-1-derived macrophages, with expression increased by lipopolysaccharide (TLR4 ligand). This upregulation is inhibited by corticosteroids used to suppress chronic allograft rejection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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