Thermo Fisher Scientific GSK3-beta Polyclonal Antibody
Rabbit polyclonal antibody against human GSK3-beta. Validated for Western blot and immunoprecipitation. Recognizes residues 370–420 of human GSK3B. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 370 and 420 of human glycogen synthase kinase-3 beta (GSK3B, UniProt ID: P49841-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat
Target Information
GSK3B (Glycogen Synthase Kinase-3 beta) is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal development, and body pattern formation. It negatively regulates glucose homeostasis and participates in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways.
GSK3B is a key component of the Wnt/beta-catenin signaling pathway, mediating beta-catenin degradation and inhibiting Wnt signaling. It is also implicated in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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