Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1A4), UltraMAB
인간 ALK 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, WB·IHC·Luminex 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제 및 동결건조 형태로 제공되며, 뇌 발달 및 종양 관련 연구용으로 최적. UltraMAB 업그레이드 버전.
- 카탈로그번호
- UM800118CF
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
The clone was previously sold as TA801287 before being upgraded to UltraMAB.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene consisting of the ALK gene and the nucleophosmin (NPM) gene.
The NPM-ALK fusion gene product is oncogenic. ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, which are absent in the transforming NPM-ALK product.
ALK shows high sequence similarity to LTK and plays an important role in brain development, affecting specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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