Thermo Fisher Scientific LSD1 Polyclonal Antibody
LSD1 단백질을 표적으로 하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat에 반응하며 Affinity Chromatography로 정제됨. 핵 위치 단백질 검출에 적합하며 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 130–380 of human KDM1 (NP_0558282) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.41 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806194 |
Product Specific Information
- Positive Samples: Cellular Location: Nucleus
- Immunogen Sequence:
LSEDEYYSEE ERNAKAEKEK KLPPPPPQAP PEEENESEPE EPSGVEGAAF QSRLPHDRMT SQEAACFPDI ISGPQQTQKV FLFIRNRTLQ LWLDNPKIQL TFEATLQQLE APYNSDTVLV HRVHSYLERH GLINFGIYKR IKPLPTKKTG KVIIIGSGVS GLAAARQLQS FGMDVTLLEA RDRVGGRVAT FRKGNYVADL GAMVVTGLGG NPMAVVSKQV NMELAKIKQK CPLYEANGQA VPKEKDEMVE Q
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a marker for transcriptional activation, functioning as a corepressor. It contains SWIRM, FAD-binding, and amine oxidase domains. LSD1 acts as part of histone deacetylase complexes and requires RCOR1/CoREST for activity on nucleosomal substrates. It may also demethylate Lys-9 of histone H3, influencing androgen receptor target gene expression. Mutations in this gene are associated with developmental abnormalities such as cleft palate and psychomotor retardation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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