Thermo Fisher Scientific TAB2 Polyclonal Antibody
Goat 폴리클로날 항체로 Human TAB2 단백질을 인식합니다. IHC(P) 검증 완료, 3–6 µg/mL 권장. 액상 형태로 0.5 mg/mL 농도이며, TBS(pH 7.3) + 0.5% BSA buffer에 보관됩니다. -20°C 보관, 동결/해동 반복 피해야 합니다.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 3–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-SKGTSSLSQQTPR (aa 161–173) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933206 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
TAB2 is an activator of MAP3K7/TAK1, which is required for IL-1 induced activation of NF-kappaB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, acting as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL-induced signaling via TNFRSF11A/RANK, influencing osteoclast development and function. TAB2 and TAB3 interact with Beclin-1, regulating autophagy by dissociating from Beclin-1 upon induction and binding TAK1. Overexpression inhibits autophagy, while depletion triggers it, suggesting TAB2 and TAB3 act as control points for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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