Thermo Fisher Scientific CD34 Monoclonal Antibody (581)
CD34 단클론항체(클론 581)는 인간 CD34 단백질을 표적으로 하는 Mouse IgG1 항체로, 줄기세포 표지 연구에 적합합니다. IHC(P) 및 유세포분석(Flow Cytometry)에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 581 |
| Immunogen | A recombinant protein of human CD34 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Kidney tissues
- Cellular location: Membrane
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It serves as a stem cell marker and may function as a surface receptor involved in receptor-mediated endocytosis, adhesion, differentiation, and proliferation of hematopoietic stem and progenitor cells. CD34 expression represents a specific developmental stage of hematopoietic cells with altered adhesion properties.
CD34 may mediate attachment of stem cells to the bone marrow extracellular matrix or stromal cells and act as a scaffold for glycans that interact with lectins on stromal or marrow components. It is also implicated in presenting carbohydrate ligands to selectins. The intracellular domain can be phosphorylated by protein kinase C, suggesting a role in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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