Thermo Fisher Scientific VprBP Polyclonal Antibody
VprBP 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합합니다. HIV-1 Vpr 결합 단백질 연구용으로 설계되었으며, 4°C 보관 및 Wet ice 배송 조건을 권장합니다.
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Thermo Fisher Scientific VprBP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human Vpr (HIV-1) binding protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
VprBP acts as both a substrate recognition component of E3 ubiquitin-protein ligase complexes and an atypical serine/threonine-protein kinase.
It plays key roles in cell cycle regulation, telomerase inhibition, histone modification, and B-cell development.
VprBP mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 and TERT.
In HIV-1 infection, it is recruited by viral Vpr to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, leading to G2 phase arrest and protection of viral proteins from degradation.
Similarly, in HIV-2 infection, it is recruited by Vpx to enhance macrophage infection efficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- A301-887A-M_VPRBP_Q9Y4B6-1_Rabbit.svg
- A301-887A-M_VPRBP_Q9Y4B6-1_Rabbit_PDP.jpeg
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