Thermo Fisher Scientific IL17A Polyclonal Antibody, Biotin
IL17A 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, 인간·마우스·랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 친화 크로마토그래피 정제, 고순도 액상 형태. 염증성 사이토카인 연구 및 면역학적 분석에 적합.
- 카탈로그번호
- IL17-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific IL17A Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 110–150 of human Interleukin-17A precursor protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17 family (IL-17A–IL-17F), signaling through the IL-17 receptor (IL-17R/CDw217).
It enhances ICAM-1 expression in fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
IL-17A supports proliferation and maturation of CD34+ hematopoietic progenitors into neutrophils and regulates NF-κB and MAPK pathways, increasing IL-6, COX-2, and nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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