Thermo Fisher Scientific JIP1 Polyclonal Antibody
JIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminal region of the human JIP1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533173 |
Target Information
The protein encoded by this gene is a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to regulate c-Jun amino-terminal kinase (Mapk8). This protein prevents MAPK8-mediated activation of transcription factors and decreases IL-1 beta and MEKK1-induced apoptosis in pancreatic beta cells. It also functions as a DNA-binding transactivator of the glucose transporter GLUT2. REST is reported to repress its expression in insulin-secreting beta cells. Mutations in this gene have been found in a type 2 diabetes family, suggesting it may be a susceptibility gene for type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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