Thermo Fisher Scientific CD11b Monoclonal Antibody (VIM12), FITC
인간 CD11b 단백질을 인식하는 마우스 단클론 항체로 FITC 형광 표지. Flow Cytometry에 적합하며 높은 형광 효율과 수용성을 제공. PBS/BSA 완충액에 보존, 4°C 암소 저장. 다양한 세포 유형에서 CD11b 발현 분석에 활용 가능.
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Thermo Fisher Scientific CD11b Monoclonal Antibody (VIM12), FITC
Applications
- Flow Cytometry (Assay-Dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VIM12 |
| Immunogen | Human CD11b (Mac-1) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with BSA |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536479 |
Product Specific Information
FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18).
The CD11b/CD18 heterodimeric complex is known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK cells, dendritic cells, and microglia.
It functions as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X—critical for cell-cell and cell-matrix interactions.
Expression levels vary among tissues and increase during monocyte maturation.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to lupus.
Additional Formats
- Unconjugated
- Alexa Fluor 700
- APC
- PE
- Custom conjugation available
Analyte Specific Reagent
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