Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11), APC
APC 형광표지된 인산화 c-Met (Tyr1234, Tyr1235) 검출용 재조합 토끼 단클론 항체로, 인간 및 마우스 시료에 반응합니다. 높은 특이성과 일관성을 가지며 Flow Cytometry에 적합합니다. Protein A/G 정제, PBS/BSA 저장, 연구용 전용입니다.
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Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11), APC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MetY12341235-6F11 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745028 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
MET (cMET) is a receptor-like tyrosine kinase linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, triggering signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development (gastrulation, muscle and neuron formation, angiogenesis, kidney development) and adult processes (wound healing, organ regeneration, tissue remodeling). Dysregulation of MET is associated with cancers such as gastric, renal, and breast, making it a significant target for cancer research and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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