Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI13E9), TrueMAB
인간 TNNI3 단백질에 특이적인 마우스 단일클론 항체로, Western blot에 적합. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol 버퍼에 보존. 심근 손상 연구 및 트로포닌 I 관련 기초 연구에 활용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13E9 |
| Immunogen | Full length human recombinant protein of human TNNI3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cardiac Troponin I (TNNI3, also known as cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle. It forms a complex with troponin C (TnC) and troponin T (TnT).
TnT binds to tropomyosin to form a troponin-tropomyosin complex, anchored by TnI binding to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release the inhibitory region of TnI, enabling myosin attachment and muscle contraction.
Blood levels of TnI and TnT serve as diagnostic indicators of heart muscle damage and help differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the TNNI3 gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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