Thermo Fisher Scientific DAZAP1 Polyclonal Antibody
Thermo Fisher Scientific의 DAZAP1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot, IHC, ICC/IF 등에 사용됩니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DAZAP1. Recombinant protein control fragment (Product #RP-102468). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640385 |
Product Specific Information
Immunogen sequence:
EPRDSKSQAP GQPGASQWGS RVVPNAANGW AGQPPPTWQQ GYGPQGMWVP AGQAIGGYGP PPAGRGAPPP PPPFTSYIVS TPPGGFPPPQ GFPQGYGAPP QFSFGYGPPP PPPDQFAPPG VPPPPA
Antigen sequence identity:
- Mouse: 98%
- Rat: 98%
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling plays a key role in development and function of male reproductive organs such as the prostate and epididymis, and also in nonreproductive organs including muscle, hair follicles, and brain. The receptor is a phosphoprotein that regulates MAP kinase signaling, and abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene are linked to complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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