Thermo Fisher Scientific KLRB1 Polyclonal Antibody
인간 KLRB1(CD161)에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 0.2 mg/mL 농도, 장기 보관 시 -20°C에서 저장 권장.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KLRB1. Recombinant protein control fragment (Product #RP-95606). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790604 |
Product Specific Information
Immunogen sequence:
KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIH
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD161) protein is a type II membrane protein with an external C terminus. It is expressed on nearly all NK cells and a subset of CD3⁺ T cells.
KLRB1 forms a homodimeric cell surface structure (40–44 kDa) and plays an inhibitory role in NK cell activity. Activation triggers acid sphingomyelinase/SMPD1 and increases intracellular ceramide, along with AKT1/PKB and RPS6KA1/RSK1 kinase activation, promoting T cell proliferation by anti-CD3 stimulation.
It binds to Gal-α(1,3)-Gal and N-acetyllactosamine epitopes, as well as CLEC2D/LLT1 ligand, inhibiting NK cell-mediated cytotoxicity and interferon-γ secretion.
The protein includes extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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