Thermo Fisher Scientific TXNL4B Recombinant Rabbit Monoclonal Antibody (002)

Applications and Tested Dilution

• Application: ELISA
• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Human Dim2/TXNL4B.

Target Information

Dim2, also known as TXNL4B (thioredoxin-like 4B) or DLP, is a 149-amino acid nuclear protein that exists as a homodimer and plays an essential role in pre-mRNA splicing. It shares 38% sequence identity with Dim1 and is required for S/G₂ transition during the cell cycle. Dim2 binds the PRP6 (U5-102K) subunit of the spliceosome.

The gene encoding Dim2 maps to human chromosome 16, which encodes over 900 genes (~3% of the human genome). Disorders associated with chromosome 16 include Rubinstein-Taybi syndrome and Crohn’s disease.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.