Thermo Fisher Scientific ACBD3 Monoclonal Antibody (OTI5F9)
ACBD3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, Flow cytometry에 적합합니다. 인간 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 및 안정적 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | – |
| Flow Cytometry (Flow) | 1:100 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F9 |
| Immunogen | Full-length human recombinant protein of ACBD3 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723827 |
Target Information
GOLPH1, also known as GCP60, was initially identified as a Golgi protein that interacts with the integral membrane protein giantin and is thought to be involved in maintaining Golgi structure.
It also interacts with Golgin-160, which can be cleaved by caspases-2, -3, and -7, leading to nuclear localization of Golgin-160 fragments.
GOLPH1 interaction with these fragments is stronger than with intact Golgin-160 and is regulated by the oxidation state of Cys-463, suggesting a coordinated mechanism for nuclear localization.
Additionally, GOLPH1 interacts with Numb, a cytosolic signaling protein involved in asymmetric cell division of neural progenitor cells, indicating that Golgi fragmentation and reconstitution during the cell cycle may regulate Numb signaling and couple cell fate with cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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