Thermo Fisher Scientific PXN Monoclonal Antibody (OTI6B7), TrueMAB
PXN 단백질을 인식하는 단일클론 항체로 Western blot에 최적화됨. 인간, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며 PBS 버퍼에 8% 트레할로스 포함. 연구용으로 세포 부착 및 신호전달 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B7 |
| Immunogen | Full length human recombinant protein of human PXN produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. Tyrosine phosphorylation of paxillin is influenced by cell-cell adhesion conditions. Paxillin interacts with FAK and Crk through its SH2 domain, independently of the extracellular matrix. Initially discovered in fibroblasts, paxillin phosphorylation also plays a role in neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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