Thermo Fisher Scientific GALNT6 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Immunogen sequence:
  DVSSREEATE KPWLKSLVSR KDHVLDLMLE AMNNLRDSMP KLQIRAPEAQ QTLFSINQSC LPGFYTPAEL KPFWERPPQD PNAPGADGKA FQKSKWTPLE TQEKEEGYKK H
• Positive Samples: U-87MG, BxPC-3
• Cellular Location: Golgi apparatus membrane, Single-pass type II membrane protein

Target Information

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.