
Thermo Fisher Scientific ERCC6L Polyclonal Antibody
Rabbit polyclonal antibody against Human ERCC6L protein. Provides high specificity for DNA helicase involved in spindle assembly checkpoint. Supplied as liquid form, unconjugated, 0.2 mg/mL concentration. Suitable for research use only, not for diagnos...
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ERCC6L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641090 |
Product Specific Information
Immunogen sequence:
IIWIRLVPLQ EEIYRKFVSL DHIKELLMET RSPLAELGVL KKLCDHPRLL SARACCLLNL GTFSAQDGNE GEDSPDVDHI DQVTDDTLME ESGKMIFLMD LL
Highest antigen sequence identity to orthologs:
- Mouse: 81%
- Rat: 81%
Target Information
ERCC6L is a DNA helicase that acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. ERCC6L acts as a tension sensor that associates with catenated DNA stretched under tension until resolved during anaphase.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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