Thermo Fisher Scientific ERCC6L Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ERCC6L if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ERCC6L,uniProtId:Q2NKX8-1,ncbiNodeId:9606,antigenRange:368-469,antigenLength:1250,antigenImageFileName:PA5-62199_ERCC6L_Q2NKX8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62199_ERCC6L_Q2NKX8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641090

Product Specific Information

Immunogen sequence: IIWIRLVPLQ EEIYRKFVSL DHIKELLMET RSPLAELGVL KKLCDHPRLL SARACCLLNL GTFSAQDGNE GEDSPDVDHI DQVTDDTLME ESGKMIFLMD LL

Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

Target Information

ERCC6L is a DNA helicase that acts as an essential component of the spindle assembly checkpoint. ERCC6L contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. ERCC6L acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.