Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (rGATA3/3870)
GATA-3 단백질을 인식하는 단클론 항체로, 유방 및 요로상피 종양 마커 연구에 적합합니다. Western blot과 면역조직화학(IHC) 분석에 사용 가능하며, Human 및 Rat 시료에 반응합니다. 단백질 A/G로 정제된 액상 항체로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rGATA3/3870 |
| Immunogen | Recombinant full-length human GATA-3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element through binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes. GATA3, a zinc finger domain-containing enhancer-binding protein, is abundantly expressed in the T-lymphocyte lineage and participates in T-cell receptor gene activation via enhancer binding. The human GATA3 gene comprises six exons over 17 kb of DNA, with two zinc fingers encoded by separate exons highly conserved with those of GATA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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