Thermo Fisher Scientific ADAR Polyclonal Antibody
인간 ADAR 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며 RNA 편집 관련 연구에 적합. 항원 친화 크로마토그래피로 정제되어 안정적인 품질 유지.
- 카탈로그번호
- PA552014
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ADAR. Recombinant protein control fragment (Product #RP-102256). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637680 |
Product Specific Information
Immunogen sequence:
SDNQPEGMIS ESLDNLESMM PNKVRKIGEL VRYLNTNPVG GLLEYARSHG FAAEFKLVDQ SGPPHEPKFV YQAKVGGRWF PAVCAHSKKQ GKQEAADAAL RVLIGENEKA ERMGFTEVTP VTGASLRRTM LLLSRSPEA
Antigen sequence identity:
- Mouse: 86%
- Rat: 85%
Target Information
Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. This process can affect gene expression and function through:
- mRNA translation (codon changes leading to altered proteins)
- pre-mRNA splicing (splice site recognition changes)
- RNA stability (nuclease recognition sequence changes)
- genetic stability in RNA virus genomes
- RNA structure-dependent activities (microRNA production, protein-RNA interactions)
ADAR edits both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing).
Cellular RNA substrates: BLCAP, GRIA2, HTR2C, GABRA3
Viral RNA substrates: HCV, VSV, MV, HDV, HIV-1
ADAR exhibits variable effects depending on the virus type:
- Antiviral: HCV (editing-dependent)
- Proviral: HDV, MV, VSV, HIV-1 (editing-dependent or independent)
It modulates viral replication through mechanisms involving EIF2AK2/PKR suppression and A-to-I editing at specific viral RNA sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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