Thermo Fisher Scientific ASH2L Polyclonal Antibody
ASH2L 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도의 액상 항체로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ASH2L (Accession Q9UBL3), corresponding to amino acid residues W421–S471 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852230 |
Product Specific Information
Antibody detects endogenous levels of total ASH2.
Target Information
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1 (isoform 1), containing a nuclear localization signal and PHD finger motif, suggesting a role as a transcription regulator.
Predicted molecular weight: 68.7 kDa
Alternative splicing may produce isoforms at 60 kDa and 56.5 kDa.
Human ASH2L proteins share 60% homology with Drosophila ash2, which regulates gene expression during early development, and 90% homology with mouse ASH2L.
ASH2L is predominantly expressed in adult heart and testis, and fetal lung and liver, with minimal expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
Expression patterns vary in leukemia cell lines such as K562, Hel, and Dami, indicating a role in hematopoiesis and leukemia association.
ASH2L has been suggested to interact with beta-tubulin and beta-catenin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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