Thermo Fisher Scientific Phospho-MEF2C (Thr20) Polyclonal Antibody
Phospho-MEF2C (Thr20) 폴리클로날 항체로 인간 MEF2C 단백질의 인산화 부위를 특이적으로 인식. Rabbit IgG 기반, Protein A 및 항원 친화 크로마토그래피로 정제. 액상 형태로 0.32 mg/mL 농도, PBS(pH 7.4) 버퍼에 나트륨 아지드 포함. 연구용으로만 사용.
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Applications
Dot blot (DB)
- Tested Dilution: 1:500
- Publications: [참고 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T20 of human MEF2C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978045 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, mouse, porcine, rat, and Xenopus based on sequence homology.
Target Information
MEF2C is a transcription activator that binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis, and is involved in vascular development. MEF2C plays an essential role in hippocampal-dependent learning and memory by regulating synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex, and necessary for proper development of megakaryocytes, platelets, and bone marrow B lymphopoiesis. It is required for B-cell survival and proliferation, efficient IgG1 antibody responses, and normal induction of germinal center B cells. Isoforms 3 and 4, which lack the repressor domain, are more active than isoforms 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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