Thermo Fisher Scientific ACL Polyclonal Antibody
ATP Citrate Lyase(ACL)를 인식하는 Rabbit Polyclonal Antibody로, WB 및 IP에 사용 가능. 인간에 반응하며 마우스, 랫, 양, 소에서도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 제품으로 4°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1051 and 1101 of human ATP citrate lyase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Sheep, and Bovine
Target Information
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
The enzyme is a tetramer (approx. molecular weight 440,000) of identical subunits.
It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with hydrolysis of ATP to ADP and phosphate.
Acetyl-CoA serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.
In nervous tissue, ATP citrate lyase may be involved in acetylcholine biosynthesis.
Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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