Thermo Fisher Scientific ALDH1A2 Polyclonal Antibody
Rabbit polyclonal antibody against human ALDH1A2 for WB, IHC, and ICC applications. Recognizes recombinant ALDH1A2 protein with high species identity to mouse and rat. Supplied as liquid, unconjugated form with 0.1 mg/mL concentration, suitable for ret...
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ALDH1A2 (Product #RP-89838) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637838 |
Product Specific Information
Immunogen sequence:
VVGSPFDPTT EQGPQIDKKQ YNKILELIQS GVAEGAKLEC GGKGLGRKGF FIEPTVFSNV TDDMRIAKEE IFGPVQEILR FKTMDEVIER ANNSDFGLVA AVFTNDINKA LTVSSAMQAG TV
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
This protein belongs to the aldehyde dehydrogenase family. The ALDH1A2 gene encodes an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, a derivative of vitamin A, acts as a hormonal signaling molecule essential for tissue development and maintenance. Studies in mouse models indicate that ALDH1A2 and CYP26A1 jointly regulate embryonic retinoic acid levels, supporting posterior organ development and preventing spina bifida. Three transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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