Thermo Fisher Scientific NSG1 Polyclonal Antibody
NSG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 친화 크로마토그래피 정제 항체입니다. 신경세포 내 수용체 재활용 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NSG1 (Accession P42857), corresponding to amino acid residues A111–V161 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851152 |
Product Specific Information
Antibody detects endogenous levels of total NSG1.
Target Information
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as NSG1 (neuron-specific proteins family member 1), P21, or D4S234E, is a single-pass type II membrane protein belonging to the NSG family.
It is highly expressed during neuronal maturation but downregulated in adult tissues.
NEEP21 localizes to Rab4-positive early endosomes in the somatodendritic neuronal compartment and is essential for receptor sorting and recycling in neurons.
It associates with GRIP1 and GluR-2, mediating GluR-2 surface expression. Disruption of this interaction leads to GluR-2 accumulation in early endosomes and altered synaptic current properties.
Additionally, NEEP21 forms a complex with the SNARE protein Syntaxin 13 (Syntaxin 12) and participates in recycling of transferrin receptors (TFRs) and neurotensin receptor 2 (NTR2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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