Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (MIL12), PE

Applications

• Flow Cytometry (Flow): Neat

Product Specifications

Additional Formats

• Unconjugated (MA5-28520)
• FITC (MA5-28521)
• Request custom conjugation

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Mouse anti-Pig wCD8 alpha antibody, clone MIL12, recognizes an epitope on the alpha chain of porcine wCD8.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a heterodimer (CD8α/CD8β) acting as a co-receptor for MHC class I molecules.
CD8α is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Upon MHC-I/peptide binding, it recruits Lck kinase, promoting lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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