Thermo Fisher Scientific CHRNA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that mediates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.

The nAChRs fall into two subclasses: the muscle-type and the neuronal-type.

• Muscle-type receptor: Pentameric glycoprotein of five membrane-spanning subunits (2 alpha 1’s, beta 1, gamma or epsilon, and delta), forming a ligand-gated ion channel.
• Neuronal nAChR: Also a pentamer, composed of alpha and beta subunits with multiple subtypes (alpha 2–8 and beta 2–4).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.