Thermo Fisher Scientific IL-12/IL-23 p40 Monoclonal Antibody (31052)

Applications

Tested Dilution

Publications

ELISA (ELISA)

0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

31052

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609028

Product Specific Information

In ELISAs, this antibody shows less than 5% cross-reactivity with recombinant human (rh) IL-12 (p35/p40 heterodimer) and rhIL-23 (p19/p40 heterodimer). No significant cross-reactivity or interference was observed with rhIL-1 alpha, rmIL-1 alpha, rhIL-1 beta, rmIL-1 beta, rhIL-1ra, rhIL-1 RI, rhIL-1 RII, rhIL-2, rhIL-2 R alpha, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-4 R, rhIL-5, rmIL-5, rhIL-5 R beta, rhIL-6, rhIL-6 R, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, rmIL-10, rhIL-11, rmIL-12, rmIL-12 p40, rhIL-13, or rmIL-13.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.