Thermo Fisher Scientific Protein C Recombinant Rabbit Monoclonal Antibody (ARC1023)
Thermo Fisher의 재조합 단클론 항체로 인간, 마우스, 랫트의 Protein C 검출에 적합. Western blot, ICC/IF, ELISA 등 다양한 응용 가능. HEK293 세포 발현, 고순도 친화 크로마토그래피 정제. 안정적 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1023 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 300–461 of human Coagulation Protein C (P04070) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849428 |
Product Specific Information
Immunogen sequence:
IALLHLAQPA TLSQTIVPIC LPDSGLAERE LNQAGQETLV TGWGYHSSRE KEAKRNRTFV LNFIKIPVVP HNECSEVMSN MVSENMLCAG ILGDRQDACE GDSGGPMVAS FHGTWFLVGL VSWGEGCGLL HNYGVYTKVS RYLDWIHGHI RDKEAPQKSW AP
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Activated Protein C contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. It is produced in the liver and composed of two polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor, forming a 55 kDa active enzyme that cleaves factor Va and VIIIa to inhibit blood coagulation. Normal human plasma concentration of active Protein C is approximately 1–3 ng/mL, while the proenzyme concentration is around 3 µg/mL. Mutations in the Protein C gene are associated with thrombophilia, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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