Thermo Fisher Scientific TMSB4X Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Thymosin beta 4 protein.

Target Information

Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family. It is found at high concentrations in the spleen, thymus, and peritoneal macrophages, where it plays a key role in cytoskeletal organization. In mammalian tissues, it modulates actin polymerization and depolymerization by forming a 1:1 complex with G-actin, preventing its polymerization into F-actin. Thymosin-beta4 is abundant in the brain, lungs, liver, kidneys, testes, and heart, and is also synthesized by myoblasts and fibroblasts. It is expressed irregularly in several hematopoietic and malignant cell lines. Additionally, it has been shown to regulate hormone secretion, macrophage migration, T cell differentiation, and stem cell cycle progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.