Thermo Fisher Scientific Cerebral Protein 1 Polyclonal Antibody
Human HUCE1 유래 합성 펩타이드로부터 제작된 Rabbit Polyclonal Antibody. Western blot에 1:500~1:1,000 희석으로 사용 가능. eNoSC 복합체 구성요소 연구에 적합하며, 액상 형태로 -20°C에 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human HUCE1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555689 |
Target Information
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to intracellular energy status by recruiting histone-modifying enzymes.
Upon glucose starvation, the elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation and subsequent dimethylation at Lys-9 (H3K9me2) by SUV39H1, forming silent chromatin in the rDNA locus.
Within the complex, RRP8 binds to H3K9me2 and likely acts as a methyltransferase, though its substrates remain unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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