Thermo Fisher Scientific Kir3.4 (KCNJ5) Polyclonal Antibody
Kir3.4(KCNJ5) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, Flow Cytometry에 사용 가능. Human, Mouse, Rat에 반응하며, 고순도의 Affinity chromatography로 정제됨. 세포막 단백질 연구 및 신경 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal human Kir3.4 (KCNJ5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913235 |
Product Specific Information
- Positive Control: Mouse heart tissue, rat heart tissue, 293T, HepG2, LOVO, human lung cancer tissue, human pancreas tissue, mouse pancreas tissue
- Subcellular Location: Membrane
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are associated with various neurotransmitter receptors in the brain. They are highly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Also known as GIRK channels, these proteins localize to the soma, dendrites, and axons of neurons.
Activated Gβγ subunits regulate Kir3 channel activity by binding to cytoplasmic domains, modulating K⁺ current. Gb3- and Gb4-containing dimers enhance K⁺ current, while Gb5-containing dimers inhibit it. Kir3 activity can also be inhibited by tyrosine phosphorylation, such as that induced by brain-derived neurotrophic factor via receptor tyrosine kinase B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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